Cell to Cell Signalling via Exosomes Through esRNA

Myocardial Regeneration via Progenitor Cell-Derived Exosomes

In the past 20 years, a variety of cell products has been evaluated in terms of their capacity to treat patients with acute myocardial infarction and chronic heart failure. Despite initial enthusiasm, therapeutic efficacy has overall been disappointing, and clinical application is costly and complex. Recently, a subset of small extracellular vesicles (EVs), commonly referred to as "exosomes," w...

Cell signalling through thromboxane A2 receptors.

Thromboxane A2 receptors (TPs) are widely distributed among different organ systems and have been localized on both cell membranes and intracellular structures. Following the initial cloning of this receptor class from human placenta, the deduced amino acid sequence predicted seven-transmembrane spanning regions, four extracellular domains and four intracellular domains, making TP a member of t...

Author's response to reviews Title: Initial activation of EpCAM signalling via cell-to-cell contact Authors:

Cell-to-cell signalling during pathogenesis.

Pathogenic bacteria produce virulence factors only when they sense they are in a location in which the energy required for pathogenesis is warranted. One environmental factor monitored by pathogens is population density, either of its own population or of the population of a host's endogenous flora. To date, four systems have been described which allow pathogens to regulate virulence genes in a...

NK cell-released exosomes

We have recently reported that human natural killer (NK) cells release exosomes that express both NK-cell markers and cytotoxic molecules. Similar results were obtained with circulating exosomes from human healthy donors. Both NK-cell derived and circulating exosomes exerted a full functional activity and killed both tumor and activated immune cells. These findings indicate that NK-cell derived...